Selected publications

HISP: A Hybrid Intelligent Approach for Identifying Directed Signaling Pathways.
Zhao XM, Li S.
Journal of Molecular Cell Biology (2017)

In this paper, we propose a novel hybrid intelligent method, namely HISP (Hybrid Intelligent approach for identifying directed Signaling Pathways), to determine both the topologies of signaling pathways and the direction of signaling flows within a pathway based on integer linear programming and genetic algorithm. By integrating the protein−protein interaction, gene expression, and gene knockout data, our HISP approach is able to determine the optimal topologies of signaling pathways in an accurate way.

CSTEA: a webserver for the Cell State Transition Expression Atlas.
Zhu G, Yang H, Chen X, Wu J, Zhang Y, Zhao XM.
Nucleic Acids Research (2017)

Here, we present CSTEA (Cell State Transition Expression Atlas), a webserver that organizes, analyzes and visualizes the time-course gene expression data during cell differentiation, cellular reprogramming and trans-differentiation in human and mouse.

PhosD: inferring kinase-substrate interactions based on protein domains.
Qin GM, Li RY, Zhao XM.
Bioinformatics (2017)

In this paper, we propose a novel probabilistic model named as PhosD to predict kinase–substrate relationships based on protein domains with the assumption that kinase–substrate interactions are accomplished with kinase–domain interactions.

GEAR: A database of Genomic Elements Associated with drug Resistance.
Wang YY, Chen WH, Xiao PP, Xie WB, Luo Q, Bork P, Zhao XM.
Scientific Reports (2017)

Here, we present GEAR (A database of Genomic Elements Associated with drug Resistance) that aims to provide comprehensive information about genomic elements (including genes, single-nucleotide polymorphisms and microRNAs) that are responsible for drug resistance.

Identifying disease associated miRNAs based on protein domains.
Qin GM, Li RY,Zhao XM.
IEEE/ACM Transactions on Computational Biology and Bioinformatics (2016)

In this work, we present a new approach to identify disease associated miRNAs based on domains, the functional and structural blocks of proteins. The results on real datasets demonstrate that our method can effectively identify disease related miRNAs with high precision.

The exploration of network motifs as potential drug targets from post-translational regulatory networks.
Zhang XD, Song J, Bork P, Zhao XM.
Scientific Reports (2016)

In this work, we construct a post-translational regulatory network (PTRN) consists of phosphorylation and proteolysis processes, which enables us to investigate the regulatory interplays between these two PTMs.

PPIM: A Protein-Protein Interaction Database for Maize.
Zhu G, Wu A, Xu XJ, Xiao PP, Lu L, Zhao XM, et al.
Plant Physiology (2016)

In this work, we present the Protein-Protein Interaction Database for Maize (PPIM), which covers 2,762,560 interactions among 14,000 proteins. The PPIM contains not only accurately predicted PPIs but also those molecular interactions collected from the literature. The database is freely available at with a user-friendly powerful interface.

Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells.
Downs CA, Kreiner L,Zhao XM, Trac P, Johnson NM, et al.
American Journal of Physiology-Lung Cellular and Molecular Physiology (2015)

In the present study, we used single channel patch-clamp recordings to examine the effect of oxidative stress, via direct application of glutathione disulfide (GSSG), on ENaC activity.

Conditional mutual inclusive information enables accurate quantification of associations in gene regulatory networks
Zhang X, Zhao J, Hao JK, Zhao XM, Chen L.
Nucleic Acids Research (2015)

In this work, to overcome the problems, we propose a novel concept, namely conditional mutual inclusive information (CMI2), to describe the regulations between genes. Furthermore, with CMI2, we develop a new approach, namely CMI2NI (CMI2-based network inference), for reverse-engineering GRNs.

Identifying cancer-related microRNAs based on gene expression data.
Zhao XM, Liu KQ, Zhu G, He F, Duval B, Richer JM, Huang DS, Jiang CJ, Hao JK, Chen L.
Bioinformatics (2015)

We present a novel computational framework to identify the cancer-related miRNAs based solely on gene expression profiles without requiring either miRNA expression data or the matched gene and miRNA expression data.

jNMFMA: a joint non-negative matrix factorization meta-analysis of transcriptomics data.
Wang HQ, Zheng CH, Zhao XM.
Bioinformatics (2015)

This article proposes a new meta-analysis method for identification of DEGs based on joint non-negative matrix factorization (jNMFMA).

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets.
Wang M, Zhao XM, Tan H, Akutsu T, Whisstock J, and Song J.
Bioinformatics (2014)

We develop a new bioinformatics tool, termed Cascleave 2.0, which builds on previous success of the Cascleave tool for predicting generic caspase cleavage sites.

A survey on computational approaches to identifying disease biomarkers based on molecular networks.
Qin G, Zhao XM.
Journal of theoretical biology (2014)

In this paper, we surveyed the recent progress on the computational approaches that have been developed to identify disease biomarkers based on molecular networks.

Human monogenic disease genes have frequently functionally redundant paralogs.
Chen WH, Zhao XM, Noort V and Bork P.
PLoS Computational Biology (2013)

We propose that functional compensation by duplication of genes masks the phenotypic effects of deleterious mutations and reduces the probability of purging the defective genes from the human population; this functional compensation could be further enhanced by higher purification selection between disease genes and their duplicates as well as their orthologous counterpart compared to non-disease genes.

eFG: an electronic resource for Fusarium graminearum.
Liu X, Zhang X, Tang WH, Chen L, Zhao XM.
Database (Oxford) (2013)

In this work, we present a comprehensive database, namely eFG (Electronic resource for Fusarium graminearum), to the community for further understanding this destructive pathogen.

NARROMI: a noise and redundancy reduction technique improves accuracy of gene regulatory network inference.
Zhang X, Liu K, Liu ZP, Duval B, Richer JM, Zhao XM, Hao JK, Chen L.
Bioinformatics (2013)

In this work, we present a novel method, namely NARROMI, to improve the accuracy of GRN inference by combining ordinary differential equation-based recursive optimization (RO) and information theory-based mutual information (MI).

Identifying dysregulated pathways in cancers from pathway interaction networks.
Liu KQ, Liu ZP, Hao JK, Chen L, Zhao XM.
BMC Bioinformatics (2012)

In this paper, we propose a novel approach to identify dysregulated pathways in cancer based on a pathway interaction network.

Identifying disease genes and module biomarkers by differential interactions.
Liu X, Liu ZP, Zhao XM, Chen L.
Journal of the American Medical Informatics Association : JAMIA (2012)

In this paper, we present a novel approach to predict disease genes and identify dysfunctional networks or modules, based on the analysis of differential interactions between disease and control samples, in contrast to the analysis of differential gene or protein expressions widely adopted in existing methods.

Prediction of drug combinations by integrating molecular and pharmacological data.
Zhao XM, Iskar M, Zeller G, Kuhn M, van Noort V, Bork P.
PLOS Computational Biology (2011)

Here, we present a novel computational approach to predict drug combinations by integrating molecular and pharmacological data.

A Systems biology approach to identify effective cocktail drugs.
Wu Z, Zhao XM, Chen L.
BMC Systems Biology (2010)

In this paper, we presented a novel network-based systems biology approach to identify effective drug combinations by exploiting high throughput data.

A discriminative approach to identifying domain-domain interactions from protein-protein interactions.
Zhao XM, Chen L, Aihara K.
Proteins (2010)

In this article, we propose a novel discriminative approach for predicting DDIs based on both protein–protein interactions (PPIs) and the derived information of non-PPIs.

FPPI: Fusarium graminearum protein-protein interaction database.
Zhao XM, Zhang XW, Tang WH, Chen L.
Journal of Proteome Research (2009)

F. graminearum protein−protein interaction (FPPI) database provides comprehensive information of protein−protein interactions (PPIs) of F. graminearum predicted based on both interologs from several PPI databases of seven species and domain−domain interactions experimentally determined based on protein structures.

Uncovering signal transduction networks from high-throughput data by integer linear programming.
Zhao XM, Wang RS, Chen L, Aihara K.
Nucleic Acids Research (2008)

In this article, we propose a novel method for uncovering signal transduction networks (STNs) by integrating protein interaction with gene expression data.

Gene function prediction using labeled and unlabeled data.
Zhao XM, Wang Y, Chen L, Aihara K.
BMC Bioinformatics (2008)

In this paper, we present a new technique, namely Annotating Genes with Positive Samples (AGPS), for defining negative samples in gene function prediction.

Protein classification with imbalanced data.
Zhao XM, Li X, Chen L, Aihara K.
Proteins (2008)

This article presents a new technique for protein classification with imbalanced data.