Selected publications in 2011

Prediction of drug combinations by integrating molecular and pharmacological data.
Zhao XM, Iskar M, Zeller G, Kuhn M, van Noort V, Bork P.
PLOS Computational Biology (2011)

Here, we present a novel computational approach to predict drug combinations by integrating molecular and pharmacological data.

Drug discovery in the age of systems biology: the rise of computational approaches for data integration.
Iskar M, Zeller G, Zhao XM, van Noort V, Bork P.
Current Opinion in Biotechnology (2011)

We discuss here how computational data integration enables systemic views on a drug's action and allows to tackle complex problems such as the large-scale prediction of drug targets, drug repurposing, the molecular mechanisms, cellular responses or side effects.

DIPOS: database of interacting proteins in Oryza sativa.
Sapkota A, Liu X, Zhao XM, Cao Y, Liu J, Liu ZP, Chen L.
Molecular BioSystems (2011)

The database of interacting proteins in Oryza sativa (DIPOS) provides comprehensive information of interacting proteins in rice, where the interactions are predicted using two computational methods, i.e., interologs and domain based methods.